Abstract: Abstract：Objective To evaluate the clinical value of small doses of solifenacin to treat children of primary nocturnal enuresis. Methods Children (n=78) of primary nocturnal enuresis were randomly divided into treatment group（39 cases） and control group（39 cases）. All children received behavioral intervention therapy, while children in the treatment group were given Solifenacin（5 mg /tablet, 1/3 tablet, 1 times a day for 3 months) orally besides behavioral therapy. Children were followed up for 3 months after the end of the treatment, and the curative effect and recurrence rate were compared between two groups. Results Compared with that of children in control group, cure rate of children in treatment group is higher at the end of treatment (89.7% vs 69.2%, P < 0.05) as well as by 3 month of follow-up time (82.1% vs 46.2%, P < 0.05). The re⁃ currence rate of children in treatment group, by three months follow-up time, was lower than that of children in control group （8.6% vs 33.3%，P < 0.05）. Conclusion Small dose of Solifenacin in addition to behavioral intervention is safe and effec⁃ tive in treatment of children with enuresis, which enhance cure rate and reduce recurrence.

Key words: nocturnal enuresis, treatment outcome, child, Solifenacin, behavioral intervention, recurrence rate