Abstract:

[Abstract]   Objective   To investigate the expression and significance of trefoil factor3(TFF3) and stromal cell de-
rived factor-1(SDF-1) in papillary thyroid carcinoma (PTC) and adjacent tissues, and to provide the basis for clinical diagnosis and prognosis evaluation.  Methods   The expressions of TFF3and SDF-1proteins in PTC and adjacent tissues were detected by immunohistochemical SP method. The relationship between expressions of TFF3, SDF-1and clinicopathological features was analyzed.   Results   (1) The positive rate and the expression level of TFF3protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stage Ⅲ/Ⅳ than those in patients of stageⅠ/Ⅱ(P<0.05). The strong positive rate of TFF3protein in stage Ⅲ/Ⅳof PTC patients was higher than that in stageⅠ/Ⅱ（P<0.01）. (2) The positive rate and the expression level of SDF-1protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stage Ⅲ/Ⅳ than those in patients of stageⅠ/Ⅱ, and were significantly higher in patients over45years old than those of patients ≤45years old (P<0.05). (3) There was a positive correlation between expression levels of TFF3and SDF-1proteins in PTC (r=0.266，P<0.05).   Conclusion   The higher expressions of TFF3and SDF-1in PTC were closely correlated with carcinogenesis and progression, which may play a significant value in judging the malignant degree and progression of PTC.

Key words: Thyroid neoplasms, carcinoma, papillary, immunohistochemistry, Trefoil Factor 3, Stromal cell derived factor 1