Abstract: Objective To explore changes of urine transferrin (TFR)， micro albumin (mALb), β2 microspheres protein (MG), α1MG and N- acetyl β-D amino group (NAG) in children with kidney injury induced by cytomegalovirus (CMV) infection, and the outcome after treatment. Methods Fifty children with CMV infection were used as case group, and 35 children of convalescence stage of upper respiratory tract infection were used as control group. The serum levels of creatinine (Scr), blood urea nitrogen (BUN), β2MG, liver function, CMV-IgM, CMV-PCR and brainstem auditory (BAEP), head CT and urine routine test, urine TFR, mALb, β2MG, α2MG and NAG were detected. The sputum CMV-PCR was detected if children combined with CMV pneumonia. Ganciclovir (5mg/kg) was given to two groups, 1/12 h i.v. for 14 d. The urine TFR， mALb, β2MG, α2MG and NAG were detected again after treatment. Results There were no significant differences in the urine mALb and TFR between the two groups. The urine levels of α1MG, NAG and β2MG were higher in case group than those of control group. The urine levels of α1MG, NAG and β2MG were decreased after 2-week treatment in case group. There were no significant differences in urine mALb and TFR before and after treatment. Conclusion The combined detection of β2MG, α1MG and NAG can predict CMV kidney damage in children at a early stage.

Key words: cytomegalovirus, kidney,  biological markers,  child, β2MG, α1MG, NAG