Tianjin Med J ›› 2015, Vol. 43 ›› Issue (11): 1304-1306.doi: 10.11958/j.issn.0253-9896.2015.11.022

• Clinical Study • Previous Articles     Next Articles

The significance of detecting serum DJ-1 protein combined with CA125 in epithelial ovarian tumors

WANG Weiming1, CAI Zhihui1, LIU Jin1, Liang Yijuan1, Ma Youju1, LIU Hui2△#br#   

  1. 1 Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding 071000, China; 2 College of Public Health of Hebei University
  • Received:2014-11-21 Revised:2015-06-06 Published:2015-11-15 Online:2015-11-15
  • Contact: LIU Hui E-mail:liuhui@hbu.cn E-mail:liuhui@hbu.cn

Abstract: Objective To explore the diagnostic value of detecting serum DJ-1 protein combined with CA125 for epithelial ovarian tumors. Methods Double antibody sandwich method and electrochemiluminescence immunoassay were used to determine the serum levels of DJ-1 protein and CA125 in 82 cases of epithelial ovarian tumors and 80 non-ovarian tumor cases (control group). The clinical significance of detecting serum DJ-1 protein combined with CA125 was analyzed. Results The expression levels of DJ-1 and CA125 were significantly higher in ovarian tumor group than those in the control group (P0.05). The critical value of serum DJ-1 was 6.800 μg/L and 6.965 μg/L in ovarian cancer group compared with the control group and non-ovarian tumor group. The sensitivity of combined detection of DJ-1 and CA125 was higher than that of any marker alone. Conclusion The detecting serum levels of DJ-1 combined with CA125 are helpful to the diagnosis of ovarian cancer, which can be a good marker of ovarian cancer and may improve the early diagnosis rate of ovarian cancer.

Key words: CA-125 antigen, ovarian neoplasms, diagnosis,  ROC curve, DJ-1