Abstract: Objective To evaluate the safety and efficacy of prophylactic uterine artery embolization (UAE) on mid - term pregnancy placental site abnormalities and massive bleeding because of placenta accreta. Methods Twenty-six patients with prophylactic UAE due to abnormal placental position during pregnancy and placental implantation in our hospital intervention center from Jun 2014 to Jun 2017 were retrospectively analyzed. All patients were treated with prophylactic uterine artery embolization. The clinical data, interventional treatment, complications and follow-up were summarized, and the safety and efficacy of UAE were analyzed. Results Twenty-six patients underwent bilateral uterine artery embolization, the technical success rate was 100%. No major complications related to intervention occurred. All patients were successfully terminated pregnancy after uterine artery embolization. No one had massive bleeding, and all patients were successfully retained the uterus. During the follow-up period, menometrorrhagia was found in a patient for more than six months, and oligomenorrhea was found in 2 patients for five months, and two patients were naturally pregnant again. Conclusion Prophylactic UAE before an obstetrical procedure is a safe and effective way to manage or prevent midterm pregnancy of placental site abnormalities and massive bleeding of placenta accreta

Key words: placenta previa, placenta accreta, pregnancy trimester, second, hemorrhage, embolization, therapeutic, uterine artery embolization