Abstract: Platelets are one of essential components of mammalian blood and play an important role in physiological and pathological reactions such as hemostasis, inflammatory response, thrombosis and rejection of organ transplantation. Platelet activation signal is the main physiological transmission mechanism that activates and induces platelets to play a physiological role, which has been the research focus in the field of physiological research in recent years. In this paper, we reviewed the new mechanisms of adhesion receptor-mediated calcium elevation, the new ideas of platelet activation mediated by pattern recognition receptors, and the new concept in platelet cGMP signaling and some other new researches.

Key words: platelet activation, signal transduction, review