Abstract: Abstract: Objective To investigate the relationship between single nucleotide polymorphism (SNP) at the calcium release-activated calcium modulator 1 (CRACM1/ORAI1) gene rs3741596 and the susceptibility of Kawasaki disease (KD), and KD merged coronary artery lesions (CALs). Methods Forty-six children diagnosed as KD and twenty-five health children were enrolled in this study. All subjects in case group were divided into CAL group and NCAL group according to the presence of CALs. Polymerase chain reaction (PCR) and direct sequencing were applied to detect the SNPs of ORAI1 gene rs3741596 in all subjects, and then further statistical analysis was conducted. Results ORAI1 gene rs3741596 SNP was detected in all subjects. There were no significant differences in the genotype distribution and allele frequency between the KD group and health control group (χ2 =0.712 and 0.499, P＞0.05). While, there were significant differences in the genotype distribution and allele frequency between the CAL group and NCAL group (χ2 =6.524 and 6.891， P＜0.05). The KD patients with G allele increased the risk of CALs (OR=5.444， 95%CI： 1.386-21.380). Conclusion The ORAI1 gene rs3741596 SNP may have no correlation with KD susceptibility, while it is related with the susceptibility to CALs in KD patients.

Key words:  polymorphism, single nucleotide, mucocutaneous lymph node syndrome, child, ORAI1 gene, coronary artery lesions (CALs)