Abstract: Abstract：Rab protein is the largest subfamily of Ras superfamily, which is the small molecule GTP binding protein, and plays an important role in the formation, transportation and fusion of vesicles. As a new member of Rab family, Rab35 is widely distributed in human tissues. It has been proved that Rab35 is related to biological characteristics such as tumor migration and invasion, which can be used as a potential tumor marker to predict prognosis and provide new targets for clinical treatment. This article reviews the origin, structure, function of Rab35 and its role in tumors.

Key words: neoplasm invasiveness, cell movement, tumor, Rab35, GTP phosphohydrolase