Abstract: Objective To explore the predictive value of serum alkaline phosphatase (ALP) and albumin levels on coronary slow flow phenomenon (CSFP). Methods A total of 3 163 patients with coronary angiography in the Department of Cardiology of our hospital were collected from January 2015 to May 2018. According to the blood flow classification method of thrombolysis in myocardial infarction (TIMI), 73 patients with TIMI blood flow grade 2 or below and no obvious coronary stenosis were taken as the CSFP group, 108 patients with TIMI blood flow grade 3 and no obvious coronary stenosis were used as the control group. The risk factors of CSFP were analyzed by binary Logistic regression and ROC curve was drawn to analyze the clinical value of serum ALP and albumin in predicting CSFP. Results In the CSFP group, the male proportion,smoking proportion, uric acid (UA) and ALP levels were all increased, while the albumin level was decreased (P＜0.05).Binary Logistic regression analysis showed that male, smoking, high ALP and UA levels were independent risk factors of CSFP, and the albumin level was protective factor of CSFP (P＜0.05). The area under ROC curves of serum albumin and ALP were 0.824 (95%CI: 0.764-0.885) and 0.637 (95%CI: 0.554-0.721) respectively. The best diagnostic threshold value of ALP was 74.71 U/L, the sensitivity 58% and the specificity 69%. The best diagnostic threshold value of albumin was 46.35 g/L,the sensitivity 74% and the specificity 82%. The Yoden index of serum albumin (0.56) in the diagnosis of CSFP was higher than that of ALP (0.27). Conclusion The serum levels of albumin and ALP have the value of predicting CSFP, and the diagnostic efficiency of serum albumin is better than that of ALP. Both of them are cheap and easy to obtain indicators, which can be used as effective predictors of CSFP.

Key words: alkaline phosphatase, serum albumin, coronary slow-flow, ROC curve, predictive