Abstract: Abstract: Objective　To explore the relationship between blood pressure variability (BPV) and ambient temperature variation in patients with hypertension complicated with acute ischemic stroke. Methods　A total of 98 patients with essential hypertension (hypertension group) and 112 patients with hypertension complicated with acute ischemic stroke (stroke group) were selected as the study subjects. Age, sex and past medical history (diabetes, coronary heart disease) were collected. And ambulatory blood pressure was measured within 3 days of admission. The 24 h mean systolic blood pressure (24 hSBP), 24 h mean diastolic blood pressure (24 hDBP), 24 h systolic blood pressure coefficient of variation (24 hSBPCV) and 24 h diastolic blood pressure coefficient of variation (24 hDBPCV) were recorded. The daily mean temperature of each patient on admission day was recorded to analyze the relationship between BPV and admission day temperature in patients with hypertension complicated with acute ischemic stroke. Results　The 24 hSBP, 24 hDBP, 24 hSBPCV and 24 hDBPCV were significantly higher in the stroke group than those in the hypertension group (P＜0.05). The 24 hDBP was lower in the ＜60 years old group than that of the 60~ < 70 years old and ≥70 years old group. The 24 hDBP was lower in the ≥70 years old group than that of the <60 years old group and 60~ < 70 years old group, and the 24 hDBPCV and 24 hDBPCV were higher in the ≥70 years old group than those of the <60 years old group and 60~ < 70 years old group. The 24 hDBP of male patients was higher than that of female patients (P＜0.05). The 24 hSBPCV and 24 hDBPCV were higher in diabetic patients than those of non-diabetic patients (P＜0.05). The 24 hSBPCV and 24 hDBPCV were higher in CHD patients than those of non-CHD patients (P＜0.05). Except for 24 hSBP, the 24 hDBP, 24 hSBPCV and 24 hDBPCV were higher in patients with admission day temperature between -13.85 and ＜4.12 ℃ than those of other patients (P＜0.05). Multiple linear regression showed that advanced and low admission daily mean temperature were the influencing factors for the increase of 24 hSBP in patients with hypertension complicated with acute ischemic stroke (P＜0.05). Advanced age was the influencing factor of 24 hDBP reduction (P＜0.05). Advanced age, history of diabetes mellitus, history of coronary heart disease and low daily mean temperature at admission were the influencing factors for the increase of 24 hSBPCV and 24 hDBPCV (P＜0.05). Conclusion　BPV is increased in patients with low temperature on admission day, advanced age, coronary heart disease or diabetes mellitus.

Key words: hypertension, stroke, diabetes mellitus, coronary disease, blood pressure variability, air temperature