Advances in the mechanism of left auricular thrombosis in patients with atrial fibrillation

doi:10.11958/20251816

Abstract

Abstract:

Atrial fibrillation (AF) is one of the most common clinical arrhythmias and a significant risk factor for thromboembolism. The left atrial appendage (LAA) is the primary site of thrombus formation in AF patients. Recent studies have explored the mechanisms of LAA thrombosis from multiple dimensions, including anatomical structure (LAA morphology and architecture), functional indicators (hemodynamic alterations), pathophysiological mechanisms (endothelial injury, inflammatory activation), systemic diseases (renal dysfunction) and genetic factors (gene polymorphisms), providing critical evidence for precise clinical anticoagulation. This article systematically reviews the latest research advances in the mechanisms of LAA thrombosis in AF patients, aiming to offer theoretical support for the accurate assessment of thromboembolic risk and the formulation of individualized anticoagulation strategies. Additionally, it lays the foundation for exploring the intrinsic relationship and mechanisms between LAA hemodynamics and heart failure as well as thromboembolic events.

Key words: atrial fibrillation, atrial appendage, thrombosis

CLC Number:

R541.7

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