Abstract: Abstract Objective: To study the effect of folic acid and compound vitamin B on plasma homocysteine level and stroke. Methods: Enzymatic cycling assay was used to measure the plasma homocysteine levels in 134 patients with stroke. By screening, patients were randomly sub-divided into folic acid and compound vitamin B intervention group (n=67) and conventional treatment (n=67) group to observe the effect of intervention. Results: The plasma homocysteine level of intervention group reduced significantly (P=0.029). Recurrence rate of intervention group was significantly lower than that of the conventional treatment group (P=0.02). Conclusion: Increasing level of plasma homocysteine is a significant risk factor of stroke. Adding folic acid and compoun vitamin B can reduce the level of plasma homocysteine and play a key role in prevention and treatment of stroke.

Key words: folic acid, compound vitamin B, stroke, homocysteine