Abstract: The safety and efficacy comparison of intravenous propafenone and loading oral propafenone for cardioversion of atrial fibrillation Abstract Object To monitor Widely used the clinical observation of intravenous propafenone for cardioversion of atrial fibrillation in elderly patients, whether it is safe out of hospital serving loading oral propafenone prescription cardioversion of atrial fibrillation. Method Clinical method selected> 60 years paroxysmal atrial fibrillation were randomly divided into two groups: intravenous loading dose of propafenone and oral propafenone loading dose group, patients with successful cardioversion hospital serving loading oral propafenone therapy out hospital . Prescription were compared cardioversion rate, incidence of side effects, the rate of emergency department visits. The results of the tow group first serving loading oral propafenone side effects (8.9% vs5.7%, p> 0.05), no statistically significant difference, while the out of hostpital treatment of side effects of propafenone loading rate (8.9% vs1.25%, p <0.05 ), emergency treatment rate (19.0% vs5%, p <0.001), according to statistically significant. Patients with atrial fibrillation in the first turn, should hospital oral loading dose, side effects can be timely manner to ensure patient safety, even if we can tolerate intravenous bolus propafenone cardioversion o f atrial fibrillation, it can not predict the loading oral service propafenone adverse reactions.

Key words: atrial fibrillation, propafenone, loading oral