Abstract: 【Objective】 Studying the mechanism of the Fosinopril combined with Fenofibrate on the preventing of diabetic retinopathy and detecting the apoptosis and apoptosis reletive gene in the level of mRNA in the retinopathsis tissue ,the VEGF oxidizing material in the retina.【Method】 150 viripotent ICR mice(100 male mice,50 female mice) were randomly divided into five groups,every group included 30 mice. A group(Sham group, common forage given,Sodium Chloride injected),B group(Model group,exposure to high-fat diet for 4 weeks,mice were injected intraperitoneally with STZ,then lavaged with Sodium Chloride for 8 weeks),C group(Fosinopril preventing group, exposure to high-fat diet for 4 weeks,mice were injected intraperitoneally with STZ,then lavaged with fosinopril for 8 weeks),D group(Fenofibrate preventing group, exposure to high-fat diet for 4 weeks,mice were injected intraperitoneally with STZ,then lavaged with fenofibrate for 8 weeks),E group(Fosinopril combined with Fenofibrate preventing group,exposure to high-fat diet for 4 weeks,mice were injected intraperitoneally with STZ,then lavaged with fosinopril combined with fenofibrate for 8 weeks), Drawing the retina to detecing the activity of GSH-PX,SOD,ROS and the concentration of MDA and VEGF,then the mice were euthanized then detected the gene of Bax and Bcl-2 in the level of mRNA through the RT-PCR and detected the apoptosis of retinal cells through the Tunel staining method in the eyes.【Results】The BG of A group is lower than that of B,C,D ,E group(p<0.05)and which of B,C,D,E group are similar(p>0.05);A group expressed more Bcl-2 in the level of mRNA and the activity of GSH-PX,SOD were higher than other four groups(P＜0.05),but the concentration of ROS,MDA,VEGF,the expression of Bax in the level of mRNA and the Tunel index were lower than the B ,C, D groups(P＜0.05);B group expressed less Bcl-2 in the level of mRNA and the activity of GSH-PX,SOD were lower than other four groups(P＜0.05),but the concentration of ROS,MDA,VEGF,the expression of Bax in the level of mRNA and the Tunel index were higher than other four groups(P＜0.05);E group expressed less Bcl-2 in the level of mRNA and the activity of GSH-PX,SOD were lower than other C,D groups(P＜0.05),but the concentration of ROS,MDA,,the expression of Bax in the level of mRNA and the Tunel index were higher than C,D groups(P＜0.05);D group expressed more Bcl-2 in the level of mRNA and the activity of GSH-PX,SOD were higher than C group(P＜0.05),but the concentration of ROS,MDA,the expression of Bax in the level of mRNA and the Tunel index were lower than C group(P＜0.05);The concentration of VEGF in the Cgroup was lower than D group(P＜0.05).【Conclusions】 Fosinopril and Fenofibrate can improve the DR through inhibit the apoptosis and oxidation can conservate the retina,but Fosinopril combinated with Fenofibrate can get the better effect.

Key words: diabetic retinopathy, diabetes complications, oxidative stress, apoptosis, disease models, animal, Fosinopril, Fenofibrate, vascular endothelial growth factor