Abstract: Toll- like receptor 4 (TLR4) plays an important role in inflammation and immune response. MicroRNAs (miRNAs) are involved in the regulation of TLR4 signaling pathway in multiple levels and various molecules, which play an important role in inflammatory reaction. A variety of miRNAs are involved in the regulation of TLR4 signaling pathway, and the TLR4 signaling pathway can induce a variety of miRNAs. Chronic diseases such as diabetes, Alzheimer’ s disease and cardiovascular disease are closely related to inflammatory response. The regulatory role of TLR4 signaling related miRNAs has attracted much attention in inflammatory diseases. In this review, the research progress of TLR4 signaling pathway related miRNAs in the regulation of inflammatory response is summarized, which provides a new research direction for the clinical diagnosis and treatment of inflammatory response related diseases.

Key words: Toll-like receptor 4, microRNAs, cytokines, inflammation, review