Research progress of targeted inhibition of NLRP3 inflammasome in spinal cord injury

doi:10.11958/20221718

Abstract

Abstract:

Spinal cord injury (SCI) is a neurotraumatic disease that is difficult to cure, and common causes include falling from height, traffic accident and heavy object injury. Inflammatory response is an immune protection produced by body in response to external stimuli. Appropriate inflammatory response can protect body from endogenous and external damage. The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome, as the most studied inflamolosome, has significantly increased expression after SCI and mediates the inflammatory cascade. This article reviews the activation mechanism of NLRP3 and relevant measures to inhibit the activation mechanism of NLRP3 after SCI.

Key words: spinal cord injury, NLR family, pyrin domain-containing 3 protein, inflammation

CLC Number:

R322.8

Figures/Tables 1

References 39

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