Abstract: To study influence of the plantain seed polysaccharide (PSP) on oxidative stress in mice of alloxan-induced diabetes. Methods Animal model was established with alloxan-induced mouse diabetes, colorimetric determination of malondialdehyde (MDA), NO and antioxidant enzymes observed PSP the impact of various biochemical indicators. Results The results demonstrate that PSP reduces the content of MDA，increase the content of NO and the activities of SOD, CAT, GSH-PX and NOS. Conclusions: PSP can enhance anti-oxidation function and free radical scavenging effect. PSP has the antioxidation effect and eliminates the free radical effect.

Key words: plantain seed polysaccharide, oxidative stress