Abstract:

[Abstract]   Objective   To investigate the relationship of omentin-1with adiponectin and inflammatory cytokines in
type 2diabetes (T2DM) patients with nonalcoholic fatty liver disease (NAFLD).  Methods   The serum levels of omentin-1 and adiponectin were assayed by enzyme-linked immunosorbent assay (ELISA) in patients of T2DM with NAFLD (group A,n=63), T2DM without NAFLD (group B,n=63)and normal control group (group C, n=70). At the same time the biochemical markers and inflammatory marker, such as tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hs-CRP) and interleukin 6(IL-6) were detected in three groups. The correlation analysis and multiple regression analysis were used to detect the association of omentin-1with adiponectin and inflammatory markers. The logistic regression was used to analyze factors influencing NAFLD in patients with T2DM.   Results   The serum levels of omentin-1 and adiponectin were significantly lower in group A [ (27.02±2.82) μg/L and (11.98±3.63) mg/L] than those of group B [(31.52±2.81) μg/L and (15.85±3.28)mg/L] and group C [(35.92±2.80) μg/L and (19.88±3.44) mg/L], and there were significantly lower levels of them in group B than those of group C (P＜0.01). The plasma omentin-1level was positively correlated with adiponectin and high density li-poprotein (HDL-C) in group A. Also the plasma omentin-1level was negatively correlated with TNF-α, IL-6, fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), visceral adipose tissue, waist, waist -to-hip ratio (WHR) and free fatty acid in group A (P＜0.05orP＜0.01). Multiple stepwise regression analysis showed that adiponectin, TNF-αand IL-6were independent factors influencing the level of plasma omentin-1. Logistic regression analysis showed that omentin-1was one of independent factors influencing T2DM combined with NAFLD (P＜0.01).   Conclusion   The incident of NAFLD in T2DM patients is related to the lower level of omentin-1, which may be influenced by adiponectin and inflammatory factors.

Key words: diabetes mellitus, type2, fatty liver, inflammation, adipokines, Omentin-1, adiponectin