Abstract: Abstract: Objective To explore the effect of renal denervation (RDN) on hypothalamus angiotensin II and oxidative stress in myocardial infarction(MI) dogs. Methods Eighteen mongrel dogs were randomly divided into MI group (n=6), RDN group (n=6) and Sham operation group (n=6). Myocardial infarction model were made in the former two groups by gelatin sponge embolization of the left anterior descending artery. One week after MI, RDN was given to dogs in RDN group. Levels of hypothalamus angiotensin Ⅱ (AngⅡ), malondialdehyde (MDA), superoxide dismutase (SOD) and expression of gp91phox protein were detected four weeks after MI. Results Compared with control group, hypothalamus AngⅡ, MDA and expression of gp91phox protein were increased in MI group (P<0.01), but SOD was decreased (P<0.01). There was a positive correlation between AngⅡ and expression of gp91phox protein (rs =0.950, P<0.01) and negative correlation between AngⅡ and SOD (rs=-0.849, P<0.01) in MI group. Compared with MI group, hypothalamus AngⅡ, MDA and expression of gp91phox protein were decreased in RDN group (P<0.01),but SOD was increased (P<0.01).Conclusion RDN can decrease the level of hypothalamus AngⅡ and the level of hypothalamus oxidative stress , improve heart function of MI dogs.

Key words: myocardial infarction, hypothalamus, angiotensin Ⅱ, oxidative stress, disease models, animal, remove renal denervation surgery