Abstract: Abstract: Objective　To investigate the correlation between IL-34, CTRP13 and unstable angina (UA) with type 2 diabetes mellitus (T2DM). Methods　A total of 150 patients admitted to the Affiliated Hospital of Chengde Medical University were collected and divided into 3 groups according to the clinical data and coronary angiography results: UA+T2DM group (n=50), UA group (n=50) and T2DM group (n=50)，and healthy people who had physical examination at the same period were selected as the control group (n=50). The serum levels of IL-34 and CTRP13 were detected by ELISA. The differences of clinical indexes were compared between the four groups. The correlation between IL-34, CTRP13 and WC, FPG, hs-CRP, Gensini score in the UA+T2DM group were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic values of IL-34 and CTRP13 for UA with T2DM. Results　The serum levels of IL-34 increased in the control group, T2DM group, UA group and UA+T2DM group in turn (all P＜0.05). The serum levels of CTRP13 decreased in the control group, UA group, T2DM group and UA+T2DM group in turn (all P＜0.05). The Gensini score was significantly higher in UA+T2DM group than that of UA group (P＜0.05). Correlation analysis showed that serum IL-34 level was positively correlated with WC, FPG, hs-CRP and Gensini score in UA+T2DM group, but negatively correlated with CTRP13 (all P＜0.05). The serum level of CTRP13 was negatively correlated with hs-CRP, FPG and Gensini score (all P＜0.05). The ROC curve showed that the areas under the curves of IL-34, CTRP13 and joint indicators were 0.784 (0.716-0.852), 0.820 (0.759-0.882) and 0.847 (0.787-0.906) in the diagnosis of UA with T2DM. Conclusion　The serum level of IL-34 is higher and the serum level of CTRP13 is lower in UA patients with T2DM. The serum levels of IL-34 and CTRP13 have predictive values for the diagnosis and the severity of coronary artery disease in UA with T2DM.

Key words: angina, unstable, diabetes mellitus, type 2, inflammation, interleukin 34, complement-C1q/TNF- related protein 13, glucose and lipid metabolism