Effects of different administration timing of butorphanol on oxidative stress and inflammatory response of ischemia-reperfusion injury induced by orthopaedic tourniquet

doi:10.11958/20212741

Abstract

Abstract:

Objective To investigate the effects of different administration timing of butorphanol on oxidative stress and inflammatory response of ischemia-reperfusion injury induced by orthopaedic tourniquet. Methods Ninety patients undergoing elective orthopedic lower limb surgery were randomly divided into the butorphanol pretreatment group (group Y), the butorphanol post-treatment group (group H) and the control group (group C), with 30 patients in each group. Subarachnoid block were used in the three groups of patients. Patients in group Y received a slow bolus of 0.02 mg/kg butorphanol intravenously 5 min before tourniquet inflation. A slow bolus of 0.02 mg/kg butorphanol was administered intravenously to patients in group H 5 min before the tourniquet was deflation. Patients in group C were not specifically addressed. Mean arterial pressure (MAP), heart rate (HR), saturation of pulse oximetry (SpO₂) values were compared before loading medication (T₀), 30 min after tourniquet inflation (T₁), 60 min after tourniquet inflation (T₂), and 5 min after tourniquet deflation (T₃). Serum tumor necrosis factor -α (TNF-α), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured at T₀ and T₃. Results There were no significant differences in HR, MAP and SpO₂ at each time point between the three groups. There were no significant differences in HR and SpO₂ at each time point between groups. Compared with T₀, MAP was significantly increased at T₂ in the group H and the group C, decreased significantly at T₃ in group Y (P<0.05). Compared with T₀, serum levels of MDA and TNF-α increased at T₃in the three groups of patients, and the serum level of SOD decreased (P<0.05). At T₃, serum levels of MDA and TNF-α were significantly lower in the group Y and the group H than those in the group C, and the serum level of SOD was significantly higher than that in the group C (P<0.05). However, there were no significant differences in the serum concentrations of MDA, SOD and TNF-α between the group Y and the group H. Conclusion Butorphanol pretreatment and post-treatment can effectively reduce the ischemia-reperfusion injury caused by tourniquet, which may be related to the inhibition of oxidative stress and inflammatory response.

Key words: butorphanol, reperfusion injury, lower extremity, oxidative stress, pretreatment, post treatment, inflammatory reaction

CLC Number:

R614

Figures/Tables 3

References 17

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