Effects of acacetin on proliferation, apoptosis and migration of hepatocellular carcinoma HepG2 cells and its mechanism

doi:10.11958/20221115

Abstract

CLC Number:

R285

Figures/Tables 7

References 22

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组别	0 h	24 h	48 h
对照组	100.00±0.00	100.00±0.00	100.00±0.00
Aca组	99.98±0.01	51.42±7.05^a	45.19±8.12^a
si-NC组	99.97±0.02	98.91±0.94^b	99.04±0.83^b
si-PINK1组	99.98±0.02	141.63±10.16^abc	157.90±18.44^abc
Aca+si-NC组	99.98±0.03	52.06±7.12^acd	46.03±8.05^acd
Aca+si-PINK1组	99.97±0.01	96.73±3.04^bde	97.86±2.07^bde
F	2.274	195.980^＊＊	133.017^＊＊

组别	0 h	24 h	48 h
对照组	100.00±0.00	100.00±0.00	100.00±0.00
Aca组	99.98±0.01	51.42±7.05^a	45.19±8.12^a
si-NC组	99.97±0.02	98.91±0.94^b	99.04±0.83^b
si-PINK1组	99.98±0.02	141.63±10.16^abc	157.90±18.44^abc
Aca+si-NC组	99.98±0.03	52.06±7.12^acd	46.03±8.05^acd
Aca+si-PINK1组	99.97±0.01	96.73±3.04^bde	97.86±2.07^bde
F	2.274	195.980^＊＊	133.017^＊＊

组别	细胞凋亡率（%）	迁移细胞数目（个/视野）	自噬小体数量（个/视野）
对照组	13.67±1.25	93.54±7.87	3.27±0.24
Aca组	46.65±3.28^a	34.49±2.85^a	8.79±0.41^a
si-NC组	15.54±1.14^b	95.97±8.12^b	3.41±0.26^b
si-PINK1组	5.42±0.28^abc	124.48±10.34^abc	1.21±0.12^abc
Aca+si-NC组	44.54±3.85^acd	38.84±3.24^acd	8.87±0.40^acd
Aca+si-PINK1组	16.64±1.43^bde	96.50±5.82^bde	4.15±0.27^bde
F	356.201^＊＊	161.704^＊＊	665.042^＊＊

组别	细胞凋亡率（%）	迁移细胞数目（个/视野）	自噬小体数量（个/视野）
对照组	13.67±1.25	93.54±7.87	3.27±0.24
Aca组	46.65±3.28^a	34.49±2.85^a	8.79±0.41^a
si-NC组	15.54±1.14^b	95.97±8.12^b	3.41±0.26^b
si-PINK1组	5.42±0.28^abc	124.48±10.34^abc	1.21±0.12^abc
Aca+si-NC组	44.54±3.85^acd	38.84±3.24^acd	8.87±0.40^acd
Aca+si-PINK1组	16.64±1.43^bde	96.50±5.82^bde	4.15±0.27^bde
F	356.201^＊＊	161.704^＊＊	665.042^＊＊

组别	Beclin-1	LC3-Ⅱ/ LC3-Ⅰ	PINK1	Parkin
对照组	0.51±0.08	0.47±0.06	0.35±0.04	0.57±0.07
Aca组	0.91±0.12^a	1.03±0.15^a	0.78±0.09^a	1.09±0.14^a
si-NC组	0.49±0.07^b	0.44±0.06^b	0.33±0.03^b	0.55±0.08^b
si-PINK1组	0.25±0.04^abc	0.16±0.02^abc	0.15±0.01^abc	0.23±0.03^abc
Aca+si-NC组	0.89±0.11^acd	0.99±0.13^acd	0.80±0.09^acd	1.06±0.12^acd
Aca+si-PINK1组	0.53±0.08^bde	0.60±0.08^bde	0.38±0.05^bde	0.54±0.06^bde
F	51.521^＊＊	77.090^＊＊	118.090^＊＊	81.446^＊＊

Effects of acacetin on proliferation, apoptosis and migration of hepatocellular carcinoma HepG2 cells and its mechanism

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