Expression of serum Sestrin2 in acute ST-segment elevation myocardial infarction and its relationship with ischemia-reperfusion injury

doi:10.11958/20220813

Abstract

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R542.2+2

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References 17

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组别	n	Sestrin2（μg/L）	MDA（μmol/L）	SOD（U/L）
对照组	50	6.53±2.01	3.97±1.05	98.87±15.87
STEMI组	124	10.36±3.18	5.32±1.56	72.32±13.12
t		7.896^＊＊	5.622^＊＊	11.354^＊＊

组别	n	Sestrin2（μg/L）	MDA（μmol/L）	SOD（U/L）
对照组	50	6.53±2.01	3.97±1.05	98.87±15.87
STEMI组	124	10.36±3.18	5.32±1.56	72.32±13.12
t		7.896^＊＊	5.622^＊＊	11.354^＊＊

组别		n	性别（男/女）			年龄（岁）			体质量指数（kg/m²）			高血压
非IRI组		52	32/20			57.17±8.51			22.12±1.49			31（59.62）
IRI组		72	44/28			59.01±8.76			22.19±1.61			46（63.89）
χ²或t			0.002			1.168			0.246			0.234
组别	糖尿病			高脂血症			心绞痛史			发病到治疗时间（h）				D to B （min）
非IRI组	10（19.23）			19（36.54）			15（28.85）			3.32±1.09				50.34±8.62
IRI组	18（25.00）			28（38.89）			24（33.33）			3.69±1.28				53.04±9.25
χ²或t	0.575			0.071			0.282			1.688				1.650
组别	cTnI （μg/L）				LVEF			Sestrin2 （μg/L）			MDA （μmol/L）		SOD （U/L）
非IRI组	19.86±4.52				0.63±0.07			7.84±2.67			4.53±1.29		79.95±14.96
IRI组	24.75±6.42				0.61±0.06			12.18±3.39			5.89±1.62		66.81±12.18
χ²或t	4.711^＊＊				1.707			7.670^＊＊			5.012^＊＊		5.383^＊＊

组别		n	性别（男/女）			年龄（岁）			体质量指数（kg/m²）			高血压
非IRI组		52	32/20			57.17±8.51			22.12±1.49			31（59.62）
IRI组		72	44/28			59.01±8.76			22.19±1.61			46（63.89）
χ²或t			0.002			1.168			0.246			0.234
组别	糖尿病			高脂血症			心绞痛史			发病到治疗时间（h）				D to B （min）
非IRI组	10（19.23）			19（36.54）			15（28.85）			3.32±1.09				50.34±8.62
IRI组	18（25.00）			28（38.89）			24（33.33）			3.69±1.28				53.04±9.25
χ²或t	0.575			0.071			0.282			1.688				1.650
组别	cTnI （μg/L）				LVEF			Sestrin2 （μg/L）			MDA （μmol/L）		SOD （U/L）
非IRI组	19.86±4.52				0.63±0.07			7.84±2.67			4.53±1.29		79.95±14.96
IRI组	24.75±6.42				0.61±0.06			12.18±3.39			5.89±1.62		66.81±12.18
χ²或t	4.711^＊＊				1.707			7.670^＊＊			5.012^＊＊		5.383^＊＊

指标	β	SE	Wald χ²	P	OR	OR95%CI
cTnI	0.267	0.201	1.765	0.184	1.306	0.881~1.937
Sestrin2	0.542	0.186	8.491	0.004	1.719	1.194~2.476
MDA	0.368	0.174	4.473	0.034	1.445	1.027~2.032
SOD	-0.645	0.248	6.764	0.009	0.525	0.323~0.853
常数项	0.205	0.103	3.961	0.047	1.228	-

Expression of serum Sestrin2 in acute ST-segment elevation myocardial infarction and its relationship with ischemia-reperfusion injury

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指标	AUC（95%CI）	敏感度（%）	特异度（%）	约登指数	截断值
Sestrin2	0.759（0.673~0.845）	76.39	67.31	0.437	9.41 μg/L
MDA	0.654（0.557~0.751）	56.94	73.08	0.300	5.28 μmol/L
SOD	0.671（0.575~0.767）	84.72	44.23	0.290	71.78 U/L

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