Tianjin Medical Journal

Tianjin Medical Journal ›› 2019, Vol. 47 ›› Issue (5): 542-548.doi: 10.11958/20190085

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Progress of study on functions of ubiquitin-specific protease 9X in promoting digestive system tumors

WANG Jie-fu, WANG Qian△   

  1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China △Corresponding Author E-mail: wangqian@tmu.edu.cn
  • Received:2019-01-15 Revised:2019-02-28 Published:2019-05-15 Online:2019-05-15

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Abstract: Abstract: Ubiquitin-specific protease 9X (USP9X) is one of the ubiquitin-specific protease(USPs) families of deubiquitinating enzymes (DUBs). USP9X is DUBs of X chromosome chain, which can play corresponding biological effects by stabilizing different substrates. USP9X plays an important role in cell signaling transduction, regulation of cell growth and migration, immune response, self-renewal and differentiation of stem cells, neurological function and carcinogenesis. Because of its important role in the development of digestive tract tumors and its feasibility as a drug target, this paper reviews the research progress of USP9X in the occurrence and development of common malignant tumors of digestive system.

Key words: deubiquitinase, USP9X, signaling pathway, gastrointestinal cancer, review