Abstract:

[Abstract] Objective  To investigate serum DJ- 1 expression and its significance in ovarian cancer. Methods  The expression levels of DJ-1 protein were detected by double antibody sandwich method in 52 cases of ovarian tumors (9 cases of benign ovarian tumors, 5 cases of borderline ovarian tumors and 38 cases of ovarian cancer,ovarian tumor group and 20 non-ovarian tumors (control group). Results  The expression of DJ-1 protein was lower in the control group than that in ovarian tumor group (P < 0.05). The expression of serum DJ-1 protein was higher in ovarian cancer than that in borderline ovarian tumors and in benign ovarian tumors. The expression of serum DJ-1 protein was higher in borderline ovarian tumors than that in benign ovarian tumors (P < 0.05).The expression of serum DJ-1 protein was higher in poorly differentiated and moderately differentiated ovarian cancer than that in high-grade differentiated ovarian cancer (P < 0.05). No significant dif? ference was found in the expression serum of DJ-1 protein between different pathological and different histological types of ovarian cancer (P > 0.05). Conclusion  DJ-1 might be used as a serum marker in the diagnosis of ovarian cancer. It might be involved in the pathogenesis of ovarian cancer，and could predit the development and prognosis of ovarian cancer.

Key words: ovarian neoplasms, carcinoma, DJ-1