Research progress on the relationship between mitochondrial dysfunction and polycystic ovary syndrome

doi:10.11958/20220686

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common disease characterized by reproductive, endocrine and metabolic abnormalities, and its pathogenesis is still unclear. Mitochondria play a key role in a variety of life activities such as energy metabolism. The impairment of mitochondrial related regulatory mechanisms can lead to its dysfunction, such as mitochondrial genome abnormalities, energy metabolism abnormalities, oxidative stress, calcium homeostasis imbalance, reduced biosynthesis, cell proliferation and apoptosis imbalance, mitochondrial dynamics disorder and autophagy abnormality. Mitochondrial dysfunction is widely recognized as a related factor of many diseases. Studies have confirmed that mitochondrial gene regulation and dysfunction are closely related to the occurrence and development of PCOS. The treatment method based on mitochondrial function repair is a new direction of PCOS treatment. This paper reviews the research progress of mitochondrial dysfunction and PCOS.

Key words: mitochondria, polycystic ovary syndrome, genome, mitochondrial, oxidative stress, mitochondrial dynamics, autophagy, follicle development, calcium homeostasis

CLC Number:

R711.75

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