Abstract: Objective  To Research on the risk factors of plasma D-dimer levels in hospitalized elderly patients with internal medicine disease. Methods   Five hundred and seventy eight hospitalized elderly patients were collected from the policlinic for old cadre’s veteran carder clinic of The Second Hospital of Tianjin Medical University. The subjects’ plasma D-dimer was measured by Automatic quantitate latex agglutination rates assay. Subjects were divided into 2 groups: the normal group (less than 0.4 mg / L), and the elevated group (greater than equal to 0.4 mg / L). Record the results of CRP, blood glucose and coagulation conventional test, and the history of diabetes, malignancies and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis of each object. Results    the average value of age, CRP, aPTT, and PT, the rate of diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis in the elevated group were statistically higher than the normal group, but the average value of TC and LDL were statistically lower than the normal group（P<0.05). the plasma D-dimer level had a significant positive correlation with the patient’s age, CRP, diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis (P<0.05). The result of Binary logistic regression analysis showed that age, CRP, diabetes, malignance, and bacterial pneumonia and (or) acute exacerbation of chronic bronchitis (P<0.05). Conclusion   Aging, diabetes, malignance, and acute inflammatory state were the important factors to lead elderly patients’ plasma D-dimer levels to elevate.

Key words: C-reactive protein, prothrombin time, diabetes mellitus, type 2, tumor, inflammation, lipids, 老年人