Abstract: Retrospective Analysis of characteristics and prognosis of hopitalized Chronic Heart Failure patients with persistent hyponatremia HUANG Jiao-hong, WANG Lin△, MA Jin-ping, YANG Yan-hua,AN Fang, LI Guang-ping Department of Gerontology, the Second Hospital Affiliated to Tianjin Medical University, Tianjin 300211, China Abstract Objective:To analyze the clinical characteristics of hospitalized Chronic Heart Failure patients with persistent hyponatremia， research the influences of persistent hyponatremia to prognosis. Methods:Collecting cases with chronic heart failure and hyponatremia at admission during recent 30 years, categorizing appropriate cases into persistent hyponatremia group and normalized sodium group on the basis of serum sodium before leaving hospital. Comparing the general characteristics, drug therapy, days of hospitalization and in-hospital mortality between two groups. Results:452 cases were enrolled, among which there were 201(44.5%)cases being persistent hyponatremia,and 251(55.5%) being normalized serum sodium. Patients with persistent hyponatremia were characterized by lower admission sodium, lower systolic blood pressure, lower left ventricular ejection fraction and lower osmosis pressure(128.6mmol/L vs. 131.9 mmol/L,120mmgH vs. 130 mmgH,39.0% vs. 46.7%,285 Osm/kgH2O vs. 291 Osm/kgH2O,respectively.all P＜0.05).Among persistent hyponatremic patients, there were less patients receiving Angiotensin-converting enzyme inhibitors(ACEI) or Angiotensin receptor blocker(ARB),but more receiving diuretics. It was the same of hospital stays between two groups, whereas higher in-hospital mortality in persistent hyponatremic patients（χ2=22.383，P＜0.001）. After adjusting for differences with multivariable analysis, the risk of in-hospital mortality was increased by 2.534 folds in persistent hyponatremic patients compared with normalized patients（χ2=10.515，P=0.001）. Conclusion:Persistent hyponatremia in hospitalized patients with chronic heart failure is characterized by more severe symptoms, poorer responses to therapy and higher in-hospital mortality. Persistent hyponatremia was an independent risk factor of in-hospital mortality.

Key words: heart failure, chronic, hyponatremia, persistent, therapy, prognosis