Research progress related to the mechanism of mesenchymal stem cell-mediated mitochondrial transfer and its application in cancer treatment

doi:10.11958/20220498

Abstract

Abstract:

The tumor microenvironment that contains mesenchymal stem cells (MSCs) plays a significant role in cancer recurrence, drug resistance and metastasis. MSCs can transfer their own mitochondria to tumor cells, enhance mitochondrial oxidative phosphorylation and promote cancer progression. Factors that interfere with mitochondrial transfer have positive effects on cancer. This paper elaborates on the mechanisms associated with the mitochondrial transfer and its related application in cancer treatment, aiming to provide novel strategies and ideas for cancer treatment.

Key words: mitochondria, mesenchymal stromal cells, stem cells, oxidative phosphorylation, neoplasms, nanotubes, microtubules

CLC Number:

R730

Figures/Tables 1

References 42

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