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Clustering Status of the Risk Factors for Premature Severe Three-vessel Coronary Disease
2011, 39 (5):
402-405 .
【Abstract】 Objective：To investigate the clustering status of the known cardiovascular risk factors for premature severe three-vessel coronary artery lesions．Methods：Following coronary angiography, 113 patients with severe three-vessel coronary artery lesions（the disease group）and another 55 patients with normal coronary artery（the control group）enrolled in the study. Clinical datas and distribution of the risk factors were analyzed．Results：（1） It was significantly different among the gender, smoking, triglyceride, high-density-lipoprotein- cholesterol（HDL-C）, obesity, hypertension, diabetes mellitus and positive family history（PFH）between the groups（P<0.05～<0.01）. The sequential contribution of the main risk factors to premature three-vessel coronary artery lesions was that gender（male）, low HDL-C, smoking, hypertriglyceridemia, hypertension, obesity and diabetes mellitus（with a OR of 10.28, 6.65, 5.26, 4.42, 3.34, 2.70, 2.68 respectively）.Multiple logistic regression analysis showed the remarkable correlation between the gender（male）, PFH, diabetes mellitus, hypertriglyceridemia, low HDL-C and the three-vessel coronary lesions. （2）Compared with the control group, clustering extent of any three risk factors or more was remarkably higher in disease group.（3）Subgroup analysis indicated that smoking, PFH, body mass index and HDL-C was associated significantly with male disease group as well as diabetes mellitus, hypertriglyceridemia, hypertension and HDL-C with female group（P<0.05）.Conclusion：Gender（male）, PFH, diabetes mellitus, low HDL-C and hypertriglyceridemia were independent risk factors for the premature severe three-vessel coronary artery lesions and the clustering of the main risk factors existed. The distribution of risk factors was remarkably different between gender.
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